The editors of the New York Evening Journal did not think it suitable for the comics section. The public didn’t much care for it. But publisher William Randolph Hearst liked it and gave it a permanent place in the Journal, beginning October 28, 1913.
Krazy Kat was a carefree, simple-minded, gender-confused cat (sometimes a he, sometimes a she), desperately in love with a mouse. It isn’t just unrequited love; Ignatz Mouse, a rather despicable little rodent, positively hates Krazy and endlessly schemes to throw bricks at Krazy’s head. Poor Krazy sees this as a sign of affection.
Add a dog – Officer Bull Pupp, a police officer who dotes on Krazy and makes it his purpose in life to prevent Ignatz from throwing bricks and to haul him off to jail when he’s caught in the act. This peculiar love triangle takes place in a surreal Arizona (or is Arizona naturally surreal?), where the strip’s creator George Herriman had a vacation home.
The premise was simplistic, the humor slapstick, but critics have loved it for 100 years. During it’s thirty-year run, it gained such admirers as H.L. Mencken, Jack Kerouac, E.E. Cummings and Willem de Kooning, and many modern cartoonists have cited the strip as a major influence on their work.
Wretched Richard's Almanac 